.Pharmacolibrary.Drugs.N_NervousSystem.N05B_Anxiolytics.N05BB01_Hydroxyzine.Hydroxyzine .Pharmacolibrary.Drugs.N_NervousSystem.N05B_Anxiolytics.N05BB01_Hydroxyzine.Hydroxyzine| name: | Hydroxyzine |
| ATC code: | N05BB01 | route: | oral |
| n-compartments | 1 |
Hydroxyzine is a first-generation antihistamine with anticholinergic and sedative properties, primarily used for the treatment of anxiety, pruritus, and as a premedication for anesthesia. It is still widely used and is approved for medical use in many countries.
Pharmacokinetic parameters observed in healthy adult volunteers following oral administration.
Paine, SW, et al., & Hincks, PR (2022). Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. Journal of veterinary pharmacology and therapeutics 45(1) 46–53. DOI:10.1111/jvp.13010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34469007
Knych, HK, et al., & McKemie, DS (2019). Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics 42(6) 617–623. DOI:10.1111/jvp.12808 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31490561
Paton, DM, & Webster, DR (1985). Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clinical pharmacokinetics 10(6) 477–497. DOI:10.2165/00003088-198510060-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2866055