.Pharmacolibrary.Drugs.N_NervousSystem.N05C_HypnoticsAndSedatives.N05CA15_Methohexital.Methohexital

Information

Methohexital is a short-acting barbiturate anesthetic agent used primarily for induction of anesthesia and for short surgical procedures. It is administered intravenously and has been used for induction in both adults and children. The drug is no longer as widely used due to the availability of newer agents but remains approved and available in some countries for specific applications such as rapid anesthesia induction and electroconvulsive therapy.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult patients after a single intravenous bolus administration.

References

1. Halbeck, E, et al., & Bolkenius, D (2018). [Drugs for intravenous induction of anesthesia: ketamine, midazolam and synopsis of current hypnotics]. Der Anaesthesist 67(8) 617–634. DOI:10.1007/s00101-018-0469-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30069734

2. Schwilden, H, et al., & Stoeckel, H (1987). Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans. Anesthesiology 67(3) 341–347. DOI:10.1097/00000542-198709000-00011 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3631609

Revisions

• 06/2025 initial generated model