.Pharmacolibrary.Drugs.N_NervousSystem.N05C_HypnoticsAndSedatives.N05CD03_Flunitrazepam.Flunitrazepam .Pharmacolibrary.Drugs.N_NervousSystem.N05C_HypnoticsAndSedatives.N05CD03_Flunitrazepam.Flunitrazepam| name: | Flunitrazepam | |
| ATC code: | N05CD03 | route: | oral |
| compartments: | 2 | |
| dosage: | 2 | mg |
| volume of distribution: | 1.1 | L |
| clearance: | 2.3 | mL/min/kg |
| other parameters in model implementation | ||
Flunitrazepam is a potent benzodiazepine derivative with hypnotic, sedative, anxiolytic, amnestic, and muscle relaxant properties. It was commonly prescribed for short-term treatment of severe insomnia and as a pre-anesthetic. Due to its high abuse potential and association with drug-facilitated crimes, it is heavily restricted or banned in many countries and is not approved in the United States.
Single oral dose pharmacokinetics in healthy adult volunteers.
Pike, A, et al., & Atack, JR (2007). Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands. Biopharmaceutics & drug disposition 28(6) 275–282. DOI:10.1002/bdd.553 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17570124