.Pharmacolibrary.Drugs.N_NervousSystem.N05C_HypnoticsAndSedatives.N05CD07_Temazepam.Temazepam

Information

Temazepam is a short-acting benzodiazepine, primarily used for the treatment of insomnia and sometimes used as a premedication for anesthetic procedures. It has hypnotic, anxiolytic, sedative, and anticonvulsant properties. Temazepam is currently an approved medication in many countries for short-term management of insomnia, especially to initiate sleep.

Pharmacokinetics

Healthy adult volunteers, mostly male and female, age range 20-50 years, after a single oral dose.

References

1. Yonkers, KA, et al., & Blumenthal, S (1992). Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. The American journal of psychiatry 149(5) 587–595. DOI:10.1176/ajp.149.5.587 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1575248

2. Wang, LL, et al., & Yun, KM (2020). Study on the Pharmacokinetics of Diazepam and Its Metabolites in Blood of Chinese People. European journal of drug metabolism and pharmacokinetics 45(4) 477–485. DOI:10.1007/s13318-020-00614-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32219697

3. Shan, Q, et al., & Yin, Y (2025). Residue Behavior and Risk Assessment of Diazepam and Its Metabolites in Crucian Carp (Carassius auratus) After Oral Administration. Journal of veterinary pharmacology and therapeutics 48(3) 212–220. DOI:10.1111/jvp.13505 PUBMED:https://pubmed.ncbi.nlm.nih.gov/40055932

Revisions

• 06/2025 initial generated model