name: | Nortriptyline |
ATC code: | N06AA10 | route: | oral |
n-compartments | 1 |
Nortriptyline is a tricyclic antidepressant primarily used in the treatment of major depressive disorder and sometimes for chronic neuropathic pain. It is an active metabolite of amitriptyline and is approved in many countries, including the US and UK, for clinical use, though newer antidepressants are often preferred due to a better side effect profile.
Pharmacokinetic parameters reported for healthy adult volunteers after oral administration.
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Koh, A, et al., & Lim, HS (2019). Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline. Journal of clinical pharmacology 59(4) 532–540. DOI:10.1002/jcph.1344 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30452773
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