.Pharmacolibrary.Drugs.N_NervousSystem.N06A_Antidepressants.N06AA21_Maprotiline.Maprotiline

Information

Maprotiline is a tetracyclic antidepressant, primarily used for the treatment of depressive disorders, especially major depressive disorder and associated anxiety. It inhibits the reuptake of norepinephrine and, to a lesser extent, serotonin. Its use has declined in favor of newer antidepressants due to safety concerns, but it is still approved and used in some countries.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult subjects after oral administration, under fasting conditions.

References

Revisions

• 06/2025 initial generated model