.Pharmacolibrary.Drugs.N_NervousSystem.N06A_Antidepressants.N06AA21_Maprotiline.Maprotiline .Pharmacolibrary.Drugs.N_NervousSystem.N06A_Antidepressants.N06AA21_Maprotiline.Maprotiline| name: | Maprotiline | |
| ATC code: | N06AA21 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 15 | L |
| clearance: | 23 | L/h |
| other parameters in model implementation | ||
Maprotiline is a tetracyclic antidepressant, primarily used for the treatment of depressive disorders, especially major depressive disorder and associated anxiety. It inhibits the reuptake of norepinephrine and, to a lesser extent, serotonin. Its use has declined in favor of newer antidepressants due to safety concerns, but it is still approved and used in some countries.
Pharmacokinetic parameters reported in healthy adult subjects after oral administration, under fasting conditions.