.Pharmacolibrary.Drugs.N_NervousSystem.N06A_Antidepressants.N06AB03_Fluoxetine.Fluoxetine

Information

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. It is an approved medication widely used today.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers (both sexes), following a single oral dose.

References

1. Deeks, ED, & Keating, GM (2008). Olanzapine/fluoxetine: a review of its use in the treatment of acute bipolar depression. Drugs 68(8) 1115–1137. DOI:10.2165/00003495-200868080-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18484802

2. Graff, DW, et al., & Patterson, JH (2001). Effect of fluoxetine on carvedilol pharmacokinetics, CYP2D6 activity, and autonomic balance in heart failure patients. Journal of clinical pharmacology 41(1) 97–106. DOI:10.1177/00912700122009746 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11225566

3. Ozdemir, V, et al., & Naranjo, CA (1996). Pharmacokinetic changes in the elderly. Do they contribute to drug abuse and dependence?. Clinical pharmacokinetics 31(5) 372–385. DOI:10.2165/00003088-199631050-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9118585

Revisions

• 06/2025 initial generated model