.Pharmacolibrary.Drugs.N_NervousSystem.N06A_Antidepressants.N06AX21_Duloxetine.Duloxetine

Information

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily in the treatment of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain. It is approved and widely used today.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after oral administration of duloxetine.

References

1. Lobo, ED, et al., & Heathman, M (2009). Population pharmacokinetics of orally administered duloxetine in patients: implications for dosing recommendation. Clinical pharmacokinetics 48(3) 189–197. DOI:10.2165/00003088-200948030-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19385712

2. Skinner, MH, et al., & Knadler, MP (2004). Effect of age on the pharmacokinetics of duloxetine in women. British journal of clinical pharmacology 57(1) 54–61. DOI:10.1046/j.1365-2125.2003.01963.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/14678340

3. Lobo, ED, et al., & Prakash, A (2014). Pharmacokinetics of orally administered duloxetine in children and adolescents with major depressive disorder. Clinical pharmacokinetics 53(8) 731–740. DOI:10.1007/s40262-014-0149-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/24989060

Revisions

• 06/2025 initial generated model