name: | Desvenlafaxine |
ATC code: | N06AX23 | route: | oral |
n-compartments | 1 |
Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant used in the treatment of major depressive disorder (MDD) in adults. It is approved by the FDA and marketed under the brand name Pristiq.
Pharmacokinetic parameters reported for healthy adult subjects after oral administration of a 100 mg tablet.
Nichols, AI, et al., & Abbas, R (2018). Population Pharmacokinetics of Desvenlafaxine: Pharmacokinetics in Korean Versus US Populations. Clinical pharmacology in drug development 7(4) 441–450. DOI:10.1002/cpdd.419 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29228473
Dolder, C, et al., & Stump, A (2010). Pharmacological and clinical profile of newer antidepressants: implications for the treatment of elderly patients. Drugs & aging 27(8) 625–640. DOI:10.2165/11537140-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20658791
Chen, YX, et al., & Zhong, DF (2015). [The enantioselective pharmacokinetic study of desvenlafaxine sustained release tablet in Chinese healthy male volunteers after oral administration]. Yao xue xue bao = Acta pharmaceutica Sinica 50(4) 486–491. PUBMED:https://pubmed.ncbi.nlm.nih.gov/26223133