.Pharmacolibrary.Drugs.N_NervousSystem.N07B_DrugsUsedInAddictiveDisorders.N07BA01_Nicotine.Nicotine_2

Information

Nicotine is a potent parasympathomimetic alkaloid found in tobacco. It acts as an agonist at nicotinic acetylcholine receptors in the central and peripheral nervous system. Clinically, nicotine has been used as an aid in smoking cessation therapies in the form of patches, gums, lozenges, nasal sprays, and inhalers. It remains approved for use in various nicotine replacement therapies.

Pharmacokinetics

Healthy adult volunteers, nicotine administered orally (chewing gum form).

References

1. Olsson Gisleskog, PO, et al., & Soons, PA (2021). Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration. Clinical pharmacokinetics 60(4) 541–561. DOI:10.1007/s40262-020-00960-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33354734

2. Hukkanen, J, et al., & Benowitz, NL (2005). Metabolism and disposition kinetics of nicotine. Pharmacological reviews 57(1) 79–115. DOI:10.1124/pr.57.1.3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15734728

3. Marchand, M, et al., & Lüdicke, F (2017). Nicotine Population Pharmacokinetics in Healthy Adult Smokers: A Retrospective Analysis. European journal of drug metabolism and pharmacokinetics 42(6) 943–954. DOI:10.1007/s13318-017-0405-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28283988

Revisions

• 06/2025 initial generated model