.Pharmacolibrary.Drugs.N_NervousSystem.N07B_DrugsUsedInAddictiveDisorders.N07BB04_Naltrexone.Naltrexone

Information

name:Naltrexone
ATC code:N07BB04
route:oral
compartments:1
dosage:50mg
volume of distribution:135L
clearance:3.5L/min
other parameters in model implementation

Naltrexone is an opioid receptor antagonist primarily used in the management of alcohol dependence and opioid dependence. It is an approved medication and acts by blocking the euphoric and sedative effects of opioids, thereby reducing the risk of relapse.

Pharmacokinetics

Pharmacokinetics of naltrexone reported in healthy adult volunteers following a single oral dose.

References

  1. Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834

  2. Kyhl, LE, et al., & Areberg, J (2016). Population pharmacokinetics of nalmefene in healthy subjects and its relation to μ-opioid receptor occupancy. British journal of clinical pharmacology 81(2) 290–300. DOI:10.1111/bcp.12805 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26483076

  3. (2006). Methylnaltrexone: MNTX. Drugs in R&D 7(6) 374–378. DOI:10.2165/00126839-200607060-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17073520

Revisions


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