name: | Methadone |
ATC code: | N07BC02 | route: | oral |
n-compartments | 2 |
Methadone is a synthetic opioid agonist primarily used for the treatment of opioid dependence and chronic pain. It acts on the same opioid receptors as morphine and heroin, but with a longer duration of action. Methadone is approved and widely used today for maintenance therapy in opioid addiction and for pain management.
Pharmacokinetic parameters reported in healthy adult subjects after oral administration.
Kokubun, H, et al., & Uezono, Y (2020). Population Pharmacokinetics of Methadone after Oral Administration in Japanese Patients with Cancer-Related Pain. Journal of pain & palliative care pharmacotherapy 34(4) 203–210. DOI:10.1080/15360288.2020.1785070 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32870067
Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834
Wiles, JR, et al., & Vinks, AA (2015). Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. The Journal of pediatrics 167(6) 1214–20.e3. DOI:10.1016/j.jpeds.2015.08.032 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26364984