.Pharmacolibrary.Drugs.N_NervousSystem.N07B_DrugsUsedInAddictiveDisorders.N07BC06_Diamorphine.Diamorphine

Information

Diamorphine, also known as heroin, is a semi-synthetic opioid derived from morphine. It functions as a potent analgesic and is used primarily for the treatment of severe pain, including palliative care and myocardial infarction-related pain. Diamorphine is a controlled substance in most countries but is approved for medical use in some, notably the UK, for pain management and palliative care.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers after intravenous administration.

References

1. Forrest, JA, et al., & Prescott, LF (1982). Clinical pharmacokinetics of paracetamol. Clinical pharmacokinetics 7(2) 93–107. DOI:10.2165/00003088-198207020-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7039926

2. Rook, EJ, et al., & Beijnen, JH (2006). Population pharmacokinetics of heroin and its major metabolites. Clinical pharmacokinetics 45(4) 401–417. DOI:10.2165/00003088-200645040-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16584286

3. Kendall, JM, & Latter, VS (2003). Intranasal diamorphine as an alternative to intramuscular morphine: pharmacokinetic and pharmacodynamic aspects. Clinical pharmacokinetics 42(6) 501–513. DOI:10.2165/00003088-200342060-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12793836

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)