.Pharmacolibrary.Drugs.N_NervousSystem.N07X_OtherNervousSystemDrugs.N07XX14_Edaravone.Edaravone

Information

Edaravone is a neuroprotective agent acting as a free radical scavenger. It is primarily used for the treatment of amyotrophic lateral sclerosis (ALS) and previously for acute ischemic stroke in some countries. It is approved in Japan and the United States (for ALS).

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects after intravenous administration.

References

1. Shimizu, H, et al., & Kondo, K (2021). Evaluation of Pharmacokinetics, Safety, and Drug-Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults. Clinical pharmacology in drug development 10(10) 1174–1187. DOI:10.1002/cpdd.925 PUBMED:https://pubmed.ncbi.nlm.nih.gov/33704925

2. Chen, X, et al., & Wang, Y (2020). Predicting the Pharmacokinetic Characteristics of Edaravone Intravenous Injection and Sublingual Tablet Through Modeling and Simulation. Clinical therapeutics 42(3) 428–438. DOI:10.1016/j.clinthera.2020.01.006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32037096

3. Li, H, et al., & Ruan, J (2012). Phase I clinical study of edaravone in healthy Chinese volunteers: safety and pharmacokinetics of single or multiple intravenous infusions. Drugs in R&D 12(2) 65–70. DOI:10.2165/11634290-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22762844

Revisions

• 06/2025 initial generated model