.Pharmacolibrary.Drugs.N_NervousSystem.N07X_OtherNervousSystemDrugs.N07XX19_SodiumPhenylbutyrateAndUrsodoxic.SodiumPhenylbutyrateAndUrsodoxic .Pharmacolibrary.Drugs.N_NervousSystem.N07X_OtherNervousSystemDrugs.N07XX19_SodiumPhenylbutyrateAndUrsodoxic.SodiumPhenylbutyrateAndUrsodoxic| name: | SodiumPhenylbutyrateAndUrsodoxicoltaurine |
| ATC code: | N07XX19 | route: | orally |
| n-compartments | 1 |
Sodium phenylbutyrate and ursodoxicoltaurine is a fixed-dose combination therapy under investigation for the treatment of amyotrophic lateral sclerosis (ALS). It combines sodium phenylbutyrate, a histone deacetylase inhibitor that may modulate protein homeostasis, with tauroursodeoxycholic acid (as ursodoxicoltaurine), a neuroprotective bile acid derivative. This combination is used as an experimental/orphan therapy and is not widely approved for general use but has received conditional or fast-track designations in certain countries for ALS.
No published clinical pharmacokinetic models available as of June 2024 for the sodium phenylbutyrate and ursodoxicoltaurine fixed-dose combination; estimates provided based on individual component parameters from published sources in healthy adults.