.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P01A_AgentsAgainstAmoebiasisAndOtherProtozoalDiseases.P01AX07_Trimetrexate.Trimetrexate

Information

name:Trimetrexate
ATC code:P01AX07
route:intravenous
n-compartments2

Trimetrexate is a dihydrofolate reductase inhibitor used historically as an antiprotozoal agent, particularly against Pneumocystis jirovecii pneumonia (PCP), primarily in immunocompromised patients such as those with HIV/AIDS. It is not widely used today and is considered an alternative therapy. The drug is administered with leucovorin to mitigate toxicity.

Pharmacokinetics

Pharmacokinetic parameters reported in adults (mean age approximately 40 years), both sexes, with HIV/AIDS, treated for PCP.

References

    Revisions

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