.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P01A_AgentsAgainstAmoebiasisAndOtherProtozoalDiseases.P01AX11_Nitazoxanide.Nitazoxanide

Information

name:Nitazoxanide
ATC code:P01AX11
route:oral
n-compartments1

Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative with broad-spectrum antiparasitic and antiviral activity. Originally developed and approved for treating protozoal infections such as Giardia lamblia and Cryptosporidium parvum, nitazoxanide is currently approved in multiple regions for the treatment of infectious diarrhea caused by these organisms in both children and adults.

Pharmacokinetics

Pharmacokinetic parameters reported for healthy adult volunteers after a single oral administration of 500 mg nitazoxanide tablet. Parameters are for its active circulating metabolite, tizoxanide.

References

  1. Rajoli, RK, et al., & Owen, A (2020). Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. medRxiv : the preprint server for health sciences None –. DOI:10.1101/2020.05.01.20087130 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32511548

  2. Zhang, CX, et al., & Arnold, SLM (2022). Pharmacokinetics and Pharmacodynamics of Clofazimine for Treatment of Cryptosporidiosis. Antimicrobial agents and chemotherapy 66(1) e0156021–None. DOI:10.1128/AAC.01560-21 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34748385

  3. Senkowski, W, et al., & Fryknäs, M (2015). Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer. Molecular cancer therapeutics 14(6) 1504–1516. DOI:10.1158/1535-7163.MCT-14-0792 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25911689

Revisions


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