.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P01B_Antimalarials.P01BA06_Amodiaquine.Amodiaquine

Information

Amodiaquine is a 4-aminoquinoline compound formerly used as a first-line antimalarial agent, particularly against Plasmodium falciparum and Plasmodium vivax, and now commonly used in artemisinin-based combination therapies (such as artesunate-amodiaquine). It is approved and in current use in multiple malaria-endemic regions globally.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers following oral administration.

References

1. Adjei, GO, et al., & Kurtzhals, JAL (2019). Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine. Current therapeutic research, clinical and experimental 90 9–15. DOI:10.1016/j.curtheres.2019.01.005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30766619

2. Guzmán, V, & Carmona-Fonseca, J (2006). [Cytochrome P-450 and the response to antimalarial drugs]. Revista panamericana de salud publica = Pan American journal of public health 19(1) 9–22. DOI:10.1590/s1020-49892006000100003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16536934

Revisions

• 06/2025 initial generated model