.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P01B_Antimalarials.P01BC01_Quinine.Quinine

Information

name:Quinine
ATC code:P01BC01
route:oral
n-compartments2

Quinine is an alkaloid derived from the bark of the cinchona tree. It is primarily used as an antimalarial agent and is effective against Plasmodium falciparum malaria. Quinine has also been used historically for treatment of muscle cramps, but its primary approved use today is for malaria treatment, especially for severe cases or in regions with chloroquine-resistant malaria.

Pharmacokinetics

Pharmacokinetics of quinine in healthy adult volunteers after oral administration.

References

  1. Kloprogge, F, et al., & Tarning, J (2014). Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda. The Journal of antimicrobial chemotherapy 69(11) 3033–3040. DOI:10.1093/jac/dku228 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24970740

  2. Le Jouan, M, et al., & Pons, G (2005). Quinine pharmacokinetics and pharmacodynamics in children with malaria caused by Plasmodium falciparum. Antimicrobial agents and chemotherapy 49(9) 3658–3662. DOI:10.1128/AAC.49.9.3658-3662.2005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16127036

  3. Lill, J, et al., & Hansten, PD (2000). Cyclosporine-drug interactions and the influence of patient age. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 57(17) 1579–1584. DOI:10.1093/ajhp/57.17.1579 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10984808

Revisions


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