modelArtesunate
Extends from Pharmacolibrary.Drugs.ATC.P.P01BE03.
Information
| name: | Artesunate | |
| ATC code: | P01BE03 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 120 | mg |
| volume of distribution: | 0.17 | L |
| clearance: | 2.8 | L/h/kg |
| other parameters in model implementation | ||
Artesunate is a semi-synthetic derivative of artemisinin, used for the treatment of severe and uncomplicated malaria. It acts rapidly against Plasmodium species and is recommended by WHO as first-line therapy for severe malaria. Artesunate is not approved in the US or EU for oral use but is used intravenously in many countries.
Pharmacokinetics
Pharmacokinetic parameters reported for adult patients with severe malaria treated with intravenous artesunate.
References
Zaloumis, SG, et al., & Simpson, JA (2014). Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria. CPT: pharmacometrics & systems pharmacology 3(11) e145–None. DOI:10.1038/psp.2014.43 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25372510
Cen, YY, et al., & Zhou, H (2018). [Research progress on pharmacokinetics and pharmacological activities of artesunate]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 43(19) 3970–3978. DOI:10.19540/j.cnki.cjcmm.20180726.010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30453725
Haghiri, A, et al., & Simpson, JA (2023). Evidence Based Optimal Dosing of Intravenous Artesunate in Children with Severe Falciparum Malaria. Clinical pharmacology and therapeutics 114(6) 1304–1312. DOI:10.1002/cpt.3041 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37666798
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)