.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P01C_AgentsAgainstLeishmaniasisAndTrypanosomiasis.P01CD01_Melarsoprol.Melarsoprol .Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P01C_AgentsAgainstLeishmaniasisAndTrypanosomiasis.P01CD01_Melarsoprol.Melarsoprol| name: | Melarsoprol | |
| ATC code: | P01CD01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 180 | mg |
| volume of distribution: | 0.5 | L |
| clearance: | 6.7 | mL/min/kg |
| other parameters in model implementation | ||
Melarsoprol is an organoarsenic compound used in the treatment of human African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei. It is particularly used for late-stage disease with central nervous system involvement. Because of its severe toxicity, especially encephalopathy, melarsoprol is reserved for cases where less toxic alternatives are not effective or not available.
Pharmacokinetic data in patients with late-stage African trypanosomiasis (adults), after intravenous administration.