.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P02D_Anticestodals.P02DA01_Niclosamide.Niclosamide

Information

name:Niclosamide
ATC code:P02DA01
route:oral
n-compartments1

Niclosamide is an anthelmintic drug primarily used to treat tapeworm infections in humans, approved for use in many countries since the 1960s. It is listed on the WHO Model List of Essential Medicines. Recently, it has gained renewed interest for repurposing against other conditions, including viral infections and cancer.

Pharmacokinetics

Single oral administration in healthy adult volunteers; pharmacokinetics reported after 2 g oral dose.

References

  1. Schweizer, MT, et al., & Yu, EY (2018). A phase I study of niclosamide in combination with enzalutamide in men with castration-resistant prostate cancer. PloS one 13(6) e0198389–None. DOI:10.1371/journal.pone.0198389 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29856824

  2. Marcelín-Jiménez, G, et al., & García-González, A (2012). Development of a method by UPLC-MS/MS for the quantification of tizoxanide in human plasma and its pharmacokinetic application. Bioanalysis 4(8) 909–917. DOI:10.4155/bio.12.41 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22533565

  3. Senkowski, W, et al., & Fryknäs, M (2015). Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer. Molecular cancer therapeutics 14(6) 1504–1516. DOI:10.1158/1535-7163.MCT-14-0792 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25911689

Revisions


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