.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P03A_EctoparasiticidesInclScabicides.P03AA04_Disulfiram.Disulfiram .Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P03A_EctoparasiticidesInclScabicides.P03AA04_Disulfiram.Disulfiram| name: | Disulfiram |
| ATC code: | P03AA04 | route: | oral |
| n-compartments | 1 |
Disulfiram is an aldehyde dehydrogenase inhibitor historically used in the treatment of chronic alcoholism as a deterrent due to the unpleasant effects caused when alcohol is consumed. It is approved for human use in several countries but its clinical use has declined.
Pharmacokinetic parameters estimated based on available pharmacology literature for healthy adult subjects; precise published PK modeling parameters are lacking.
Foster, PM, et al., & Gray, TJ (1984). Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat. Environmental health perspectives 57 207–217. DOI:10.1289/ehp.8457207 PUBMED:https://pubmed.ncbi.nlm.nih.gov/6499806
Krall, LP (1984). Glyburide (DiaBeta): a new second-generation hypoglycemic agent. Clinical therapeutics 6(6) 746–762. PUBMED:https://pubmed.ncbi.nlm.nih.gov/6439409
Johnson, DJ, et al., & Valentine, WM (1996). The measurement of 2-thiothiazolidine-4-carboxylic acid as an index of the in vivo release of CS2 by dithiocarbamates. Chemical research in toxicology 9(5) 910–916. DOI:10.1021/tx960006v PUBMED:https://pubmed.ncbi.nlm.nih.gov/8828929