.Pharmacolibrary.Drugs.P_AntiparasiticProductsInsecticidesAndRepellents.P03A_EctoparasiticidesInclScabicides.P03AB01_Clofenotane.Clofenotane

Information

name:Clofenotane
ATC code:P03AB01
route:oral
n-compartments1

Clofenotane, also known as DDT (dichlorodiphenyltrichloroethane), is an organochlorine insecticide that was widely used for the control of vector-borne diseases like malaria. Due to environmental persistence and toxic effects in humans and wildlife, its use is now highly restricted or banned in most countries.

Pharmacokinetics

No specific pharmacokinetic parameters in humans have been directly reported in peer-reviewed literature for therapeutic or vector control dosing. Data below are estimated based on animal and environmental studies and extrapolation.

References

  1. Handa, M, et al., & Beg, S (2021). Therapeutic potential of nanoemulsions as feasible wagons for targeting Alzheimer's disease. Drug discovery today 26(12) 2881–2888. DOI:10.1016/j.drudis.2021.07.020 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34332094

  2. Zhao, H (2011). Lead optimization in the nondrug-like space. Drug discovery today 16(3-4) 158–163. DOI:10.1016/j.drudis.2010.12.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21147254

  3. Sharma, T, et al., & Mazumdar, D (2019). Polymorphism of xenobiotic metabolizing gene and susceptibility of epithelial ovarian cancer with reference to organochlorine pesticides exposure. Experimental biology and medicine (Maywood, N.J.) 244(16) 1446–1453. DOI:10.1177/1535370219878652 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31569996

Revisions


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