modelClofenotane
Extends from Pharmacolibrary.Drugs.ATC.P.P03AB01.
Information
| name: | Clofenotane | |
| ATC code: | P03AB01 | route: | oral |
| compartments: | 1 | |
| dosage: | 50 | mg |
| volume of distribution: | 2.6 | L |
| clearance: | 0.01 | L/kg/h |
| other parameters in model implementation | ||
Clofenotane, also known as DDT (dichlorodiphenyltrichloroethane), is an organochlorine insecticide that was widely used for the control of vector-borne diseases like malaria. Due to environmental persistence and toxic effects in humans and wildlife, its use is now highly restricted or banned in most countries.
Pharmacokinetics
No specific pharmacokinetic parameters in humans have been directly reported in peer-reviewed literature for therapeutic or vector control dosing. Data below are estimated based on animal and environmental studies and extrapolation.
References
Handa, M, et al., & Beg, S (2021). Therapeutic potential of nanoemulsions as feasible wagons for targeting Alzheimer's disease. Drug discovery today 26(12) 2881–2888. DOI:10.1016/j.drudis.2021.07.020 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34332094
Zhao, H (2011). Lead optimization in the nondrug-like space. Drug discovery today 16(3-4) 158–163. DOI:10.1016/j.drudis.2010.12.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21147254
Sharma, T, et al., & Mazumdar, D (2019). Polymorphism of xenobiotic metabolizing gene and susceptibility of epithelial ovarian cancer with reference to organochlorine pesticides exposure. Experimental biology and medicine (Maywood, N.J.) 244(16) 1446–1453. DOI:10.1177/1535370219878652 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31569996
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)