modelCyfluthrin
Extends from Pharmacolibrary.Drugs.ATC.P.P03BA01.
Information
| name: | Cyfluthrin | |
| ATC code: | P03BA01 | route: | oral |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 1.5 | L |
| clearance: | 0.05 | L/kg/h |
| other parameters in model implementation | ||
Cyfluthrin is a synthetic pyrethroid insecticide used primarily for control of pests in agriculture, public health, and domestic settings. It is not approved for human therapeutic use but is widely used as a pesticide on crops, livestock, and in households.
Pharmacokinetics
No published pharmacokinetic parameters for human administration found; estimations based on pyrethroid class data and animal studies.
References
Wang, Z, et al., & Diao, J (2020). Thermal effects on tissue distribution, liver biotransformation, metabolism and toxic responses in Mongolia racerunner (Eremias argus) after oral administration of beta-cyfluthrin. Environmental research 185 109393–None. DOI:10.1016/j.envres.2020.109393 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32203733
Hays, SM, et al., & Krishnan, K (2009). Derivation of Biomonitoring Equivalents for cyfluthrin. Regulatory toxicology and pharmacology : RTP 55(3) 268–275. DOI:10.1016/j.yrtph.2009.09.002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19751788
Vanacker, M, et al., & Crépet, A (2020). Aggregate and cumulative chronic risk assessment for pyrethroids in the French adult population. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 143 111519–None. DOI:10.1016/j.fct.2020.111519 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32619558
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)