modelCypermethrin
Extends from Pharmacolibrary.Drugs.ATC.P.P03BA02.
Information
| name: | Cypermethrin | |
| ATC code: | P03BA02 | route: | oral |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 2 | L |
| clearance: | 0.5 | L/kg/h |
| other parameters in model implementation | ||
Cypermethrin is a synthetic pyrethroid insecticide widely used in agriculture and household pest control. It acts as a neurotoxin by disrupting sodium channel function in nerve cells of insects. While not approved for human therapeutic use, cypermethrin is prevalent as an antiparasitic agent for animals and is a common environmental contaminant in cases of pesticide poisoning.
Pharmacokinetics
Estimated pharmacokinetic parameters for cypermethrin in humans after oral exposure, since no defined clinical PK models or published studies in humans are available. Data are roughly extrapolated from animal studies and general organophosphate/pyrethroid class literature.
References
Côté, J, et al., & Bouchard, M (2014). A novel toxicokinetic modeling of cypermethrin and permethrin and their metabolites in humans for dose reconstruction from biomarker data. PloS one 9(2) e88517–None. DOI:10.1371/journal.pone.0088517 PUBMED:https://pubmed.ncbi.nlm.nih.gov/24586336
Vanacker, M, et al., & Crépet, A (2020). Aggregate and cumulative chronic risk assessment for pyrethroids in the French adult population. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 143 111519–None. DOI:10.1016/j.fct.2020.111519 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32619558
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)