modelDecamethrin

Extends from Pharmacolibrary.Drugs.ATC.P.P03BA03.

Information

name:Decamethrin
ATC code:P03BA03
route:topical
compartments:1
dosage:1mg
volume of distribution:1L
clearance:0
other parameters in model implementation

Decamethrin (also known as deltamethrin) is a synthetic pyrethroid insecticide commonly used for the control of a broad range of insect pests in agriculture, public health, and veterinary medicine. It is not used as a human drug, but rather as an ectoparasiticide. It is not approved for therapeutic use in humans.

Pharmacokinetics

No pharmacokinetic parameters available in the published literature for human, animal, or in medical context; decamethrin's main use is as an insecticide applied topically to surfaces or animals.

References

  1. González Audino, P, et al., & Picollo, MI (2004). Role of enhanced detoxication in a deltamethrin-resistant population of Triatoma infestans (Hemiptera, Reduviidae) from Argentina. Memorias do Instituto Oswaldo Cruz 99(3) 335–339. DOI:10.1590/s0074-02762004000300018 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15273811

Parameters

TypeNameDefaultDescription
Modelica.Units.SI.Massweight (from PK_1C)75patient weight (kg)
Modelica.Units.SI.SpecificVolumeVdPerKg (from PK_1C)0.9Volume of distribution (L/kg)
Modelica.Units.SI.MassFractionF (from PK_1C)0.8bioavailiability (0-1)
Pharmacolibrary.Types.ClearanceCl (from PK_1C)20clearance
Modelica.Units.SI.TimeadminTime (from PK_1C)60first administration time (s)
Modelica.Units.SI.TimeadminDuration (from PK_1C)600administration duration (s)
Modelica.Units.SI.TimeadminPeriod (from PK_1C)8*60*60period of administration (default 8 hours)(s)
Pharmacolibrary.Types.MassadminMass (from PK_1C)1000administration mass (mg)
IntegeradminCount (from PK_1C)8number of dose administered (1)
Pharmacolibrary.Types.VolumeVd (from PK_1C)VdPerKg*weightVolume of distribution (m3)
Pharmacolibrary.Types.MassConcentrationCmin (from PK_1C)0.004minimal therapeutic range
Pharmacolibrary.Types.MassConcentrationCmax (from PK_1C)0.008minimal therapeutic range
Pharmacolibrary.Types.MassConcentrationCtox_peak (from PK_1C)0.012toxicity peak level
Pharmacolibrary.Types.MassConcentrationCtox_trough (from PK_1C)0.006toxicity trough level

Connectors

TypeNameDefaultDescription
Types.ConcentrationOutputC_central (from PK_1C)
Interfaces.ConcentrationPort_bcentralCPort (from PK_1C)

Components

TypeNameDefaultDescription
Pharmacokinetic.NoPerfusedTissueCompartmentcentral (from PK_1C)
Pharmacokinetic.ClearanceDrivenEliminationelim (from PK_1C)
Sources.PeriodicDoseperiodicDose (from PK_1C)
Modelica.Units.SI.Timet1_2 (from PK_1C)elimination half-life

Revisions

  • 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)