.Pharmacolibrary.Drugs.R_RespiratorySystem.R01A_DecongestantsAndOtherNasalPreparationsForTopical.R01AA08_Naphazoline.Naphazoline

Information

Naphazoline is an imidazoline derivative with sympathomimetic and vasoconstrictive properties. It is primarily used as a topical nasal decongestant and in ophthalmic preparations to reduce redness and swelling in the eyes. It works by stimulating alpha-adrenergic receptors, leading to vasoconstriction of mucosal blood vessels. While it is approved and still widely used in many over-the-counter decongestant nasal sprays and eye drops, caution is advised due to potential rebound congestion and systemic absorption effects.

Pharmacokinetics

No published clinical pharmacokinetic studies in humans with quantified model parameters found; parameters are estimated based on typical values for similar topical and nasal alpha-agonists.

References

Revisions

• 06/2025 initial generated model