name: | Phenylephrine |
ATC code: | R01AB01 | route: | oral |
n-compartments | 1 |
Phenylephrine is a selective alpha-1 adrenergic receptor agonist used primarily as a nasal decongestant, and less commonly as a vasopressor in hypotensive states. It is available over the counter for relief of nasal congestion due to colds or allergies. It is approved for use in many countries, though its oral efficacy for decongestion has been questioned.
Pharmacokinetic parameters reported in healthy adult volunteers, both male and female, aged 18-55, after oral administration.
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Atkinson, HC, et al., & Anderson, BJ (2015). Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. European journal of clinical pharmacology 71(2) 151–158. DOI:10.1007/s00228-014-1788-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25475358
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