.Pharmacolibrary.Drugs.R_RespiratorySystem.R01A_DecongestantsAndOtherNasalPreparationsForTopical.R01AB01_Phenylephrine.Phenylephrine

Information

name:Phenylephrine
ATC code:R01AB01
route:oral
n-compartments1

Phenylephrine is a selective alpha-1 adrenergic receptor agonist used primarily as a nasal decongestant, and less commonly as a vasopressor in hypotensive states. It is available over the counter for relief of nasal congestion due to colds or allergies. It is approved for use in many countries, though its oral efficacy for decongestion has been questioned.

Pharmacokinetics

Pharmacokinetic parameters reported in healthy adult volunteers, both male and female, aged 18-55, after oral administration.

References

  1. Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219

  2. Atkinson, HC, et al., & Anderson, BJ (2015). Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. European journal of clinical pharmacology 71(2) 151–158. DOI:10.1007/s00228-014-1788-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25475358

  3. Vincent, J, et al., & Reid, JL (1986). Racial differences in drug responses--a comparative study of trimazosin and alpha 1-adrenoceptor responses in normotensive Caucasians and West Africans. British journal of clinical pharmacology 21(4) 401–408. DOI:10.1111/j.1365-2125.1986.tb05214.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3011048

Revisions


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