.Pharmacolibrary.Drugs.R_RespiratorySystem.R01B_NasalDecongestantsForSystemicUse.R01BA53_PhenylephrineCombination.PhenylephrineCombination .Pharmacolibrary.Drugs.R_RespiratorySystem.R01B_NasalDecongestantsForSystemicUse.R01BA53_PhenylephrineCombination.PhenylephrineCombination| name: | PhenylephrineCombinations |
| ATC code: | R01BA53 | route: | oral |
| n-compartments | 1 |
Phenylephrine, used as a nasal decongestant, is often combined with other agents (such as antihistamines or analgesics) to treat symptoms of common cold or allergic rhinitis. It acts as a selective alpha-1 adrenergic receptor agonist, leading to vasoconstriction and reduction of nasal congestion. Oral combination preparations are still approved and available today.
Pharmacokinetic estimates for healthy adult volunteers after oral administration of combination phenylephrine tablets (e.g., co-administered with antihistamines or paracetamol).
Atkinson, HC, et al., & Anderson, BJ (2015). Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. European journal of clinical pharmacology 71(8) 931–938. DOI:10.1007/s00228-015-1876-1 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26022219
Atkinson, HC, et al., & Anderson, BJ (2015). Increased bioavailability of phenylephrine by co-administration of acetaminophen: results of four open-label, crossover pharmacokinetic trials in healthy volunteers. European journal of clinical pharmacology 71(2) 151–158. DOI:10.1007/s00228-014-1788-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25475358