.Pharmacolibrary.Drugs.R_RespiratorySystem.R02A_ThroatPreparations.R02AD02_Lidocaine.Lidocaine

Information

Lidocaine is a local anesthetic and antiarrhythmic drug commonly used to numb tissue in a specific area and to treat ventricular arrhythmias. It works by blocking sodium channels, thereby inhibiting nerve impulse initiation and conduction. It is still widely approved and used today for both anesthesia and emergency treatment of arrhythmias.

Pharmacokinetics

Adult healthy volunteers, intravenous bolus injection.

References

1. Foong, KW, et al., & Loh, PS (2024). Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review. Clinical pharmacokinetics 63(5) 623–643. DOI:10.1007/s40262-024-01373-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38703307

2. Heath, C, et al., & Sommerfield, D (2023). Perioperative intravenous lidocaine use in children. Paediatric anaesthesia 33(5) 336–346. DOI:10.1111/pan.14608 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36424875

3. Crouch, CE, et al., & Fernandez-Bustamante, A (2023). Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation. Anesthesiology 138(1) 71–81. DOI:10.1097/ALN.0000000000004422 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36512707

Revisions

• 06/2025 initial generated model