.Pharmacolibrary.Drugs.R_RespiratorySystem.R02A_ThroatPreparations.R02AD03_Cocaine.Cocaine .Pharmacolibrary.Drugs.R_RespiratorySystem.R02A_ThroatPreparations.R02AD03_Cocaine.Cocaine| name: | Cocaine |
| ATC code: | R02AD03 | route: | intravenous |
| n-compartments | 2 |
Cocaine is a powerful central nervous system stimulant derived from the leaves of the Erythroxylum coca plant. It was historically used as a local anesthetic and vasoconstrictor, especially in ophthalmology and otolaryngology. Due to its high potential for abuse, dependence, and serious adverse effects, the medical use of cocaine is now extremely limited, and it is primarily classified as a controlled substance in most countries.
Pharmacokinetic parameters based on adult healthy volunteers after intravenous administration.
Rook, EJ, et al., & Beijnen, JH (2006). Population pharmacokinetics of heroin and its major metabolites. Clinical pharmacokinetics 45(4) 401–417. DOI:10.2165/00003088-200645040-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16584286
van Amsterdam, J, & van den Brink, W (2025). Explaining the high mortality among opioid-cocaine co-users compared to opioid-only users. A systematic review. Journal of addictive diseases 43(2) 121–131. DOI:10.1080/10550887.2024.2331522 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38504419
Fattinger, K, et al., & Verotta, D (2000). Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine. European journal of clinical pharmacology 56(4) 305–310. DOI:10.1007/s002280000147 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10954344