.Pharmacolibrary.Drugs.R_RespiratorySystem.R02A_ThroatPreparations.R02AD03_Cocaine.Cocaine_1

Information

Cocaine is a powerful central nervous system stimulant derived from the leaves of the Erythroxylum coca plant. It was historically used as a local anesthetic and vasoconstrictor, especially in ophthalmology and otolaryngology. Due to its high potential for abuse, dependence, and serious adverse effects, the medical use of cocaine is now extremely limited, and it is primarily classified as a controlled substance in most countries.

Pharmacokinetics

Pharmacokinetic parameters for healthy adult subjects after oral administration.

References

1. Pal, D, & Mitra, AK (2006). MDR- and CYP3A4-mediated drug-drug interactions. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 1(3) 323–339. DOI:10.1007/s11481-006-9034-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18040809

2. Fattinger, K, et al., & Verotta, D (2000). Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine. European journal of clinical pharmacology 56(4) 305–310. DOI:10.1007/s002280000147 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10954344

3. Heltsley, R, et al., & Cone, EJ (2011). Oral fluid drug testing of chronic pain patients. I. Positive prevalence rates of licit and illicit drugs. Journal of analytical toxicology 35(8) 529–540. DOI:10.1093/anatox/35.8.529 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22004671

Revisions

• 06/2025 initial generated model