.Pharmacolibrary.Drugs.R_RespiratorySystem.R03B_OtherDrugsForObstructiveAirwayDiseasesInhalants.R03BB04_TiotropiumBromide.TiotropiumBromide

Information

name:TiotropiumBromide
ATC code:R03BB04
route:inhalation
n-compartments2

Tiotropium bromide is a long-acting anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma. It is inhaled and acts by blocking muscarinic receptors in the airways, leading to bronchodilation. Tiotropium is approved and widely used in clinical practice today for maintenance therapy in patients with COPD and for some patients with asthma.

Pharmacokinetics

Pharmacokinetic model in healthy adult volunteers after single 18 mcg inhaled dose using DPI. Parameters based on non-compartmental and compartmental analysis in published clinical trial data.

References

  1. Panning, CA, & DeBisschop, M (2003). Tiotropium: an inhaled, long-acting anticholinergic drug for chronic obstructive pulmonary disease. Pharmacotherapy 23(2) 183–189. DOI:10.1592/phco.23.2.183.32082 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12587807

  2. Deeks, ED (2015). Olodaterol: a review of its use in chronic obstructive pulmonary disease. Drugs 75(6) 665–673. DOI:10.1007/s40265-015-0371-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25773742

  3. Wang, Z, et al., & Luo, Z (2020). Pharmacokinetics and safety of tiotropium+olodaterol 5 μg/5 μg fixed-dose combination in Chinese patients with COPD. Pulmonary pharmacology & therapeutics 63 101944–None. DOI:10.1016/j.pupt.2020.101944 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32916296

Revisions


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