.Pharmacolibrary.Drugs.R_RespiratorySystem.R03C_AdrenergicsForSystemicUse.R03CC03_Terbutaline.Terbutaline

Information

Terbutaline is a selective beta-2 adrenergic agonist primarily used as a bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease (COPD), and other conditions associated with reversible airway obstruction. It is also sometimes used off-label as a tocolytic agent to delay preterm labor. Terbutaline is approved for use in many countries, though there are restrictions on its use in obstetric indications in some regions due to safety concerns.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers after oral administration.

References

1. Ahlström, H, et al., & Rosenborg, J (1999). Pharmacokinetics of bambuterol during oral administration to asthmatic children. British journal of clinical pharmacology 48(3) 299–308. DOI:10.1046/j.1365-2125.1999.00028.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/10510139

2. Ye, Y, et al., & Tan, W (2015). The Lipid-lowering Effects of R-bambuterol in Healthy Chinese Volunteers: A Randomized Phase I Clinical Study. EBioMedicine 2(4) 356–364. DOI:10.1016/j.ebiom.2015.02.006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26137575

Revisions

• 06/2025 initial generated model