.Pharmacolibrary.Drugs.R_RespiratorySystem.R03D_OtherSystemicDrugsForObstructiveAirwayDiseases.R03DA04_Theophylline.Theophylline_1

Information

name:Theophylline_1
ATC code:R03DA04_1
route:intravenous
n-compartments2

Theophylline is a methylxanthine drug used as a bronchodilator, primarily for asthma and COPD. Although it has been largely superseded by newer drugs, it continues to have clinical utility in specific cases.

Pharmacokinetics

Two-compartment pharmacokinetic model in healthy adults, after intravenous administration.

References

  1. Yano, I, et al., & Hori, R (1993). Population pharmacokinetics of theophylline. I: Intravenous infusion to children in the acute episode of asthma. Biological & pharmaceutical bulletin 16(1) 59–62. DOI:10.1248/bpb.16.59 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8369754

  2. Yano, I, et al., & Hori, R (1993). Population pharmacokinetics of theophylline. II: Intravenous infusion to patients with stable chronic airway obstruction. Biological & pharmaceutical bulletin 16(5) 501–505. DOI:10.1248/bpb.16.501 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8364499

  3. Moore, ES, et al., & Grasela, TH (1989). The population pharmacokinetics of theophylline in neonates and young infants. Journal of pharmacokinetics and biopharmaceutics 17(1) 47–66. DOI:10.1007/BF01059087 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2715932

Revisions


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