.Pharmacolibrary.Drugs.R_RespiratorySystem.R03D_OtherSystemicDrugsForObstructiveAirwayDiseases.R03DA05_Aminophylline.Aminophylline

Information

name:Aminophylline
ATC code:R03DA05
route:intravenous
n-compartments1

Aminophylline is a bronchodilator consisting of theophylline and ethylenediamine, used in the management of asthma, chronic obstructive pulmonary disease (COPD), and sometimes apnea of prematurity. It is administered orally or intravenously, though its use has declined due to the availability of newer agents. Aminophylline is still approved and used in certain clinical contexts.

Pharmacokinetics

PK parameters reported in healthy adult volunteers after intravenous administration.

References

  1. Moore, ES, et al., & Grasela, TH (1989). The population pharmacokinetics of theophylline in neonates and young infants. Journal of pharmacokinetics and biopharmaceutics 17(1) 47–66. DOI:10.1007/BF01059087 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2715932

  2. Frymoyer, A, et al., & Chock, VY (2020). Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatric research 88(6) 871–877. DOI:10.1038/s41390-020-01140-8 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32919393

  3. Park, K, et al., & Halstead, ES (2018). No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 19(8) e425–e432. DOI:10.1097/PCC.0000000000001608 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29927879

Revisions


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