.Pharmacolibrary.Drugs.R_RespiratorySystem.R03D_OtherSystemicDrugsForObstructiveAirwayDiseases.R03DA05_Aminophylline.Aminophylline_2

Information

name:Aminophylline_2
ATC code:R03DA05_2
route:oral
n-compartments1

Aminophylline is a bronchodilator consisting of theophylline and ethylenediamine, used in the management of asthma, COPD, and sometimes apnea of prematurity. It is administered orally or intravenously, though use has declined in favor of newer drugs.

Pharmacokinetics

PK parameters estimated for oral administration in adults; limited direct PK data for aminophylline, estimates are drawn from theophylline oral PK.

References

  1. Moore, ES, et al., & Grasela, TH (1989). The population pharmacokinetics of theophylline in neonates and young infants. Journal of pharmacokinetics and biopharmaceutics 17(1) 47–66. DOI:10.1007/BF01059087 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2715932

  2. Karlsson, MO, et al., & Kelman, AW (1991). Population pharmacokinetics of rectal theophylline in neonates. Therapeutic drug monitoring 13(3) 195–200. DOI:10.1097/00007691-199105000-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1926271

  3. Koysooko, R, et al., & Geadsomnuig, S (1987). Pharmacokinetics of oral theophylline in Thai asthmatic children. Asian Pacific journal of allergy and immunology 5(2) 179–185. PUBMED:https://pubmed.ncbi.nlm.nih.gov/3449080

Revisions


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