name: | Aminophylline_2 |
ATC code: | R03DA05_2 | route: | oral |
n-compartments | 1 |
Aminophylline is a bronchodilator consisting of theophylline and ethylenediamine, used in the management of asthma, COPD, and sometimes apnea of prematurity. It is administered orally or intravenously, though use has declined in favor of newer drugs.
PK parameters estimated for oral administration in adults; limited direct PK data for aminophylline, estimates are drawn from theophylline oral PK.
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Karlsson, MO, et al., & Kelman, AW (1991). Population pharmacokinetics of rectal theophylline in neonates. Therapeutic drug monitoring 13(3) 195–200. DOI:10.1097/00007691-199105000-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1926271
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