.Pharmacolibrary.Drugs.R_RespiratorySystem.R05C_ExpectorantsExclCombinationsWithCoughSuppressant.R05CB01_Acetylcysteine.Acetylcysteine_1

Information

Acetylcysteine (N-acetylcysteine, NAC) is a mucolytic agent used to break down mucus, particularly in the lungs. It is also used as an antidote for acetaminophen (paracetamol) overdose. Approved and widely used in clinical practice today.

Pharmacokinetics

Pharmacokinetic parameters in patients after intravenous administration of NAC for acetaminophen overdose (standard 21-hour protocol).

References

1. Forrest, JA, et al., & Prescott, LF (1982). Clinical pharmacokinetics of paracetamol. Clinical pharmacokinetics 7(2) 93–107. DOI:10.2165/00003088-198207020-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7039926

2. Anderson, SM, et al., & Patel, RV (2011). Intravenous N-acetylcysteine in the prevention of contrast media-induced nephropathy. The Annals of pharmacotherapy 45(1) 101–107. DOI:10.1345/aph.1P275 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21205947

3. Fayed, MS, et al., & Coles, LD (2023). Population Pharmacokinetic Model of N-Acetylcysteine During Periods of Recurrent Hypoglycemia in Healthy Volunteers. Clinical pharmacology in drug development 12(12) 1234–1240. DOI:10.1002/cpdd.1338 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37937383

Revisions

• 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)