.Pharmacolibrary.Drugs.R_RespiratorySystem.R05C_ExpectorantsExclCombinationsWithCoughSuppressant.R05CB13_DornaseAlfaDesoxyribonuc.DornaseAlfaDesoxyribonuc .Pharmacolibrary.Drugs.R_RespiratorySystem.R05C_ExpectorantsExclCombinationsWithCoughSuppressant.R05CB13_DornaseAlfaDesoxyribonuc.DornaseAlfaDesoxyribonuc| name: | DornaseAlfaDesoxyribonuclease |
| ATC code: | R05CB13 | route: | inhalation |
| n-compartments | 1 |
Dornase alfa is a recombinant form of human deoxyribonuclease I (rhDNase) used to break down extracellular DNA in the sputum of cystic fibrosis patients, thereby reducing sputum viscosity and improving pulmonary function. It is approved as a mucolytic therapy primarily in cystic fibrosis and remains in current clinical use.
PK parameters described for cystic fibrosis patients, both adult and pediatric, following standard inhalation administration.