.Pharmacolibrary.Drugs.R_RespiratorySystem.R05D_CoughSuppressantsExclCombinationsWithExpectorant.R05DA03_Hydrocodone.Hydrocodone

Information

name:Hydrocodone
ATC code:R05DA03
route:oral
n-compartments1

Hydrocodone is a semi-synthetic opioid used for the management of moderate to moderately severe pain or as an antitussive (cough suppressant). It is commonly combined with acetaminophen or ibuprofen. Hydrocodone is approved for use in several countries, including the United States, but it is a controlled substance due to its abuse potential.

Pharmacokinetics

Pharmacokinetic model in healthy adult subjects after oral administration.

References

  1. Thigpen, JC, et al., & Harirforoosh, S (2019). Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children. European journal of drug metabolism and pharmacokinetics 44(5) 591–609. DOI:10.1007/s13318-019-00552-0 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31006834

  2. Melhem, MR, et al., & Robinson, CY (2013). Population pharmacokinetic analysis for hydrocodone following the administration of hydrocodone bitartrate extended-release capsules. Clinical pharmacokinetics 52(10) 907–917. DOI:10.1007/s40262-013-0081-6 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23719682

  3. Bond, M, et al., & Spiegelstein, O (2017). Effect of Food on the Pharmacokinetics of Single- and Multiple-Dose Hydrocodone Extended Release in Healthy Subjects. Clinical drug investigation 37(12) 1153–1163. DOI:10.1007/s40261-017-0575-3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28948482

Revisions


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