.Pharmacolibrary.Drugs.R_RespiratorySystem.R05D_CoughSuppressantsExclCombinationsWithExpectorant.R05DA05_OpiumAlkaloidsWithMorphi.OpiumAlkaloidsWithMorphi

Information

Opium alkaloids with morphine comprise a combination of opium-derived alkaloids, predominantly morphine, used historically as antitussive (cough suppressant) agents. The combination acts primarily through opioid receptors, providing relief from severe cough. Given the potential for abuse and side effects, its use is now largely obsolete or restricted in many countries, replaced by safer alternatives. It is not widely approved for use today.

Pharmacokinetics

Pharmacokinetic parameters are estimated based on typical oral morphine preparations in adults, as no specific population PK model or clinical study of pharmacokinetics for this fixed combination is available.

References

1. Lugo, RA, & Kern, SE (2002). Clinical pharmacokinetics of morphine. Journal of pain & palliative care pharmacotherapy 16(4) 5–18. DOI:10.1080/j354v16n04_02 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14635822

2. Lugo, RA, & Kern, SE (2004). The pharmacokinetics of oxycodone. Journal of pain & palliative care pharmacotherapy 18(4) 17–30. DOI:10.1300/j354v18n04_03 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15760805

3. Liu, T, et al., & Ivaturi, V (2016). Mechanistic Population Pharmacokinetics of Morphine in Neonates With Abstinence Syndrome After Oral Administration of Diluted Tincture of Opium. Journal of clinical pharmacology 56(8) 1009–1018. DOI:10.1002/jcph.696 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26712409

Revisions

• 06/2025 initial generated model