.Pharmacolibrary.Drugs.R_RespiratorySystem.R05D_CoughSuppressantsExclCombinationsWithExpectorant.R05DA09_Dextromethorphan.Dextromethorphan

Information

Dextromethorphan is a cough suppressant used in the treatment of dry cough. It acts on the central nervous system to reduce the cough reflex. Widely used as an over-the-counter antitussive, it is also being investigated for use in neurological disorders. Dextromethorphan is approved and widely used today.

Pharmacokinetics

Pharmacokinetics reported in healthy adult volunteers; oral administration.

References

1. Abduljalil, K, et al., & Fuhr, U (2010). Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan. Clinical pharmacology and therapeutics 88(5) 643–651. DOI:10.1038/clpt.2010.137 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20881950

2. Nagai, N, et al., & Ogata, H (1996). Pharmacokinetics and polymorphic oxidation of dextromethorphan in a Japanese population. Biopharmaceutics & drug disposition 17(5) 421–433. DOI:10.1002/(SICI)1099-081X(199607)17:5<421::AID-BDD421>3.0.CO;2-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8830977

3. Marasanapalle, VP, et al., & Zack, J (2024). Investigation of the Differences in the Pharmacokinetics of CYP2D6 Substrates, Desipramine, and Dextromethorphan in Healthy African Subjects Carrying the Allelic Variants CYP2D6*17 and CYP2D6*29, When Compared with Normal Metabolizers. Journal of clinical pharmacology 64(5) 578–589. DOI:10.1002/jcph.2366 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37803948

Revisions

• 06/2025 initial generated model