.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AA09_Doxylamine.Doxylamine

Information

name:Doxylamine
ATC code:R06AA09
route:oral
n-compartments1

Doxylamine is a first-generation antihistamine belonging to the ethanolamine class. It is primarily used as a short-term treatment for insomnia and as a nighttime sleep aid. Doxylamine is also found in combination with other agents as an ingredient for relief of symptoms of allergy, common cold, or as part of antiemetic preparations. It is approved and marketed in many countries.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult volunteers; oral tablet administration.

References

  1. Luna, BG, et al., & Greenblatt, DJ (1989). Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives. Journal of clinical pharmacology 29(3) 257–260. DOI:10.1002/j.1552-4604.1989.tb03323.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/2723113

  2. Gill, SK, et al., & Koren, G (2011). Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). Therapeutic drug monitoring 33(1) 115–119. DOI:10.1097/FTD.0b013e3181ff8bc5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21079545

Revisions


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