.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AA59_DoxylamineCombinations.DoxylamineCombinations .Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AA59_DoxylamineCombinations.DoxylamineCombinations| name: | DoxylamineCombinations |
| ATC code: | R06AA59 | route: | oral |
| n-compartments | 1 |
Doxylamine is a first-generation antihistamine of the ethanolamine class, commonly used as a short-term treatment for insomnia and as a component in combination products for relief of symptoms associated with allergies, common cold, and nausea/vomiting of pregnancy. In some countries, doxylamine is still approved and widely used, particularly in over-the-counter sleep aids, while in others it may be restricted or used mainly in fixed-dose combination products.
Parameters estimated for healthy adult individuals based on known single-agent doxylamine pharmacokinetics, as no source available for combination products with this ATC code.
Gill, SK, et al., & Koren, G (2011). Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). Therapeutic drug monitoring 33(1) 115–119. DOI:10.1097/FTD.0b013e3181ff8bc5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21079545