.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AC01_Mepyramine.Mepyramine .Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AC01_Mepyramine.Mepyramine| name: | Mepyramine |
| ATC code: | R06AC01 | route: | oral |
| n-compartments | 1 |
Mepyramine (also known as pyrilamine) is a first-generation antihistamine used primarily as an antiallergic and antipruritic agent. It acts as an H1-receptor antagonist and was originally used for allergies, hay fever, and the common cold. Use has significantly declined due to sedative effects, and it is not widely used as a systemic antihistamine today but may be found in some topical preparations or combination over-the-counter medicines.
Pharmacokinetic parameters are estimated for an average healthy adult; published clinical PK data for mepyramine are extremely limited.