.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AX12_Terfenadine.Terfenadine

Information

Terfenadine is a non-sedating antihistamine that was formerly used to treat allergic rhinitis and other allergy symptoms. It acts as an H1 receptor antagonist. Due to its association with QT prolongation and risk of serious arrhythmias (notably Torsades de Pointes), terfenadine has been withdrawn or discontinued in many countries and is no longer approved for clinical use.

Pharmacokinetics

Pharmacokinetic parameters in healthy adult subjects following oral administration.

References

1. Lalonde, RL, et al., & Gaudreault, J (1996). Population pharmacokinetics of terfenadine. Pharmaceutical research 13(6) 832–838. DOI:10.1023/a:1016036624935 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8792418

2. Paton, DM, & Webster, DR (1985). Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clinical pharmacokinetics 10(6) 477–497. DOI:10.2165/00003088-198510060-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2866055

3. Wilkinson, GR (1996). Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans. Journal of pharmacokinetics and biopharmaceutics 24(5) 475–490. DOI:10.1007/BF02353475 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9131486

Revisions

• 06/2025 initial generated model