.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AX19_Azelastine.Azelastine

Information

Azelastine is a selective histamine H1 receptor antagonist with additional anti-inflammatory and mast cell stabilizing properties. It is primarily used for the symptomatic relief of allergic rhinitis and conjunctivitis. It is available as a nasal spray and ophthalmic solution, and is approved for use in many countries, including for prescription and over-the-counter use.

Pharmacokinetics

PK parameters reported for healthy adult volunteers after single and multiple intranasal administrations.

References

1. Wolthers, OD (2013). New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis. Recent patents on inflammation & allergy drug discovery 7(3) 223–228. DOI:10.2174/1872213x113079990019 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23862774

2. Simons, FE, & Simons, KJ (1999). Clinical pharmacology of new histamine H1 receptor antagonists. Clinical pharmacokinetics 36(5) 329–352. DOI:10.2165/00003088-199936050-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10384858

Revisions

• 06/2025 initial generated model