.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AX26_Fexofenadine.Fexofenadine

Information

Fexofenadine is a second-generation antihistamine used to treat allergy symptoms such as hay fever (allergic rhinitis) and urticaria (hives). It is a non-sedating antihistamine and is widely approved for clinical use globally for symptomatic relief of allergic conditions.

Pharmacokinetics

Pharmacokinetics in healthy adult volunteers following a single oral dose.

References

1. Piscitelli, J, et al., & Ma, JD (2023). Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic Approach. Therapeutic drug monitoring 45(4) 539–545. DOI:10.1097/FTD.0000000000001052 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36645711

2. Pal, D, & Mitra, AK (2006). MDR- and CYP3A4-mediated drug-herbal interactions. Life sciences 78(18) 2131–2145. DOI:10.1016/j.lfs.2005.12.010 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16442130

3. Simons, FE (2002). Comparative pharmacology of H1 antihistamines: clinical relevance. The American journal of medicine 113 Suppl 9A 38S–46S. DOI:10.1016/s0002-9343(02)01436-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12517581

Revisions

• 06/2025 initial generated model