.Pharmacolibrary.Drugs.R_RespiratorySystem.R06A_AntihistaminesForSystemicUse.R06AX27_Desloratadine.Desloratadine

Information

name:Desloratadine
ATC code:R06AX27
route:oral
n-compartments1

Desloratadine is a non-sedating second-generation antihistamine used to treat symptoms associated with allergic rhinitis and chronic idiopathic urticaria. It is the active metabolite of loratadine and is widely approved and used today.

Pharmacokinetics

Pharmacokinetic parameters reported following single oral administration of 5 mg desloratadine in healthy adult volunteers.

References

  1. Liu, T, et al., & Liu, X (2024). Simultaneously Predicting Pharmacokinetics of Loratadine and Desloratadine in Children Using a Whole-Body Physiologically Based Pharmacokinetic Model. Journal of clinical pharmacology None –. DOI:10.1002/jcph.6120 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39171895

  2. Affrime, M, et al., & Cayen, M (2002). Effect of race and sex on single and multiple dose pharmacokinetics of desloratadine. Clinical pharmacokinetics 41 Suppl 1 21–28. DOI:10.2165/00003088-200241001-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12169043

  3. Simons, FE (2002). Comparative pharmacology of H1 antihistamines: clinical relevance. The American journal of medicine 113 Suppl 9A 38S–46S. DOI:10.1016/s0002-9343(02)01436-5 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12517581

Revisions


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